Department of Developmental and Molecular Biology

at Einstein

Polarity in the ovary
In vertebrates the first asymmetries are established during oogenesis along the animal-vegetal axis, but the underlying molecular mechanisms are poorly understood. Bucky ball (Buc) was identified in zebrafish as a novel vertebrate specific regulator of oocyte polarity, acting through unknown molecular interactions. Our studies show that Buc protein localizes to the Balbiani body, a conserved, asymmetric structure in oocytes that requires Buc for its formation. Through transgenic and genetic approaches we are investigating how Buc and its binding partners regulate oocyte polarity and follicle cell fates.




Questions we address in the Marlow Lab: