Department of Developmental and Molecular Biology

at Einstein


The polarity factor Bucky ball associates with the centrosome and promotes microtubule rearrangements to establish the oocyte axis in zebrafish.Forbes MM., Draper BW, Marlow FL. Development. Development 2015:doi:10.1242/dev.129023.

Primordial Specification and Migration. Marlow FL. F1000Research 2015, 4(F1000 Faculty Rev):1462 (doi: 10.12688/f1000research.6995.1).

Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis.Campbell PD, Heim AE, Smith M, Marlow FL. Development. 2015 Sep 1;142(17):2996-3008. doi: 10.1242/dev.124586. Epub 2015 Aug 7. PMID: 26253407.

Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L. Development 2015 Aug 1;142(15):2704-18. doi: 10.1242/dev.119800. Epub 2015 Jul 9. PMID: 26160902.

Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells. Forbes MM, Rothhämel S, Jenny A, Marlow FL. Cell Reports PMID: 26119733. This manuscript has been retracted.

Dynamic visualization of transcription and RNA subcellular localization in zebrafish. Campbell PD, Chao JA, Singer RH, Marlow FL. Development. 2015 Apr 1;142(7):1368-74. doi: 10.1242/dev.118968. Epub 2015 Mar 10.PMID: 25758462.

Unique function of Kinesin Kif5A in localization of mitochondria in axons. Campbell PD, Shen K, Sapio M,Glenn T, Talbot WS, Marlow FL. J Neurosci. 2014 Oct 29;34(44):14717-32. doi: 10.1523/JNEUROSCI.2770-14.2014.PMID: 25355224.

Zebrafish Vasa is required for germ cell differentiation and maintenance. Hartung O, Forbes MM, Marlow FL. Molecular Reproduction and Development. Mol Reprod Dev. 2014 Oct;81(10):946-61. doi: 10.1002/mrd.22414. Epub 2014 Sep 25.
PMID: 25257909.

Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish. Feng L, Jiang H, Wu P, Marlow FL.Dev Biol. 2014 Sep 18. pii: S0012-1606(14)00467-9. doi: 10.1016/j.ydbio.2014.09.010. [Epub ahead of print]
PMID: 25238963.

Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. Ge X, Grotjahn D, Welch E, Lyman-Gingerich J, Holguin C, Dimitrova E, Abrams EW, Gupta T, Marlow FL, Yabe T, Adler A, Mullins MC, Pelegri F. PLoS Genet. 2014 Jun 26;10(6):e1004422. doi:10.1371/journal.pgen.1004422. eCollection 2014 Jun. PMID: 24967891.

Monitoring dynamic glycosylation in vivo using supersensitive click chemistry. Jiang H, Zheng T, Lopez-Aguilar A, Feng L, Kopp F, Marlow FL, Wu P.
Bioconjug Chem. 2014 Apr 16;25(4):698-706. doi: 10.1021/bc400502d. Epub 2014 Mar 14.PMID: 24499412

Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Heim AE, Hartung O, Rothhämel S, Ferreira E, Jenny A, Marlow FL. Development. 2014 Feb;141(4):842-54. doi: 10.1242/dev.090449.PMID: 24496621.

The Integrator Complex Subunit 6 (Ints6) is a Negative Regulator of the Vertebrate Organizer. Kapp LD, Abrams EW, Marlow FL, Mullins MC. PLOSGenetics. 2013 Oct;9(10):e1003822. doi: 10.1371/journal.pgen.1003822. Epub 2013 Oct 31.PMID: 24204286.

notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.Zaucker A, Mercurio S, Sternheim N, Talbot WS, Marlow FL. Disease Models and Mechanisms. Dis Model Mech. 2013 Sep;6(5):1246-59. doi: 10.1242/dmm.012005. Epub 2013 May 29. PMID: 23720232.

Analysis of zebrafish kinesin-1 kif5 heavy chain genes during zebrafish development. Campbell, PD, Marlow FL. Gene Expression Patterns. Epub 2013 May 15. 2013 Oct;13(7):271-9. doi: 10.1016/j.gep.2013.05.002.

The adhesion GPCR Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Li X, Roszko I, Sepich DS, Ni M, Hamm H, Marlow FL*, Solnica-Krezel L.* Development. 2013 Jul;140(14):3028-39. doi: 10.1242/dev.094839. PMID: 23821037 *cocorresponding authors.

The Chromosomal Passenger Protein Birc5b Organizes Microfilaments and Germ Plasm in the Zebrafish Embryo. Nair S, Marlow FL, Abrams E, Kapp L, Mullins MC, Pelegri F. PLoS Genet. 2013 April; 9(4): e1003448. Published online 2013 April 18. doi: 10.1371/journal.pgen.1003448PMCID: PMC3630083.

Comparative gene expression analysis of the fmnl family of formins during zebrafish embryogenesis and implications for tissue specific functions. Santos-Ledo A, Jenny A, Marlow FL. Gene Expression Patterns. 2012 Oct 13. pii: S1567-133X(12)00076-2. doi: 10.1016/j.gep.2012.09.002.

Brambleberry, a novel nuclear envelope associated protein, regulates nuclear membrane fusion during cleavage stage development. Abrams EW, Zhang H, Marlow FL, Kapp L, and Mullins MC. Cell. 2012 3 Aug; 150(3) pp. 521 – 532.

Mutations in vacuolar H+ATPase subunits lead to biliary developmental defects in zebrafish. EuaClaire SF, Cui S, Ma L, Marous J, Marlow FL, Gupta T, Burgess HA, Abrams EW, Kapp LD, Granato M, Mullins MC, Matthews RP. Dev Biol. 2012 May 15; 365 (2): 434-44. Epub 2012 Mar 16. PMID: 22465374.

Raising the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study. Besanceney C, Jiang H, Zheng T, Feng L, Soriano Del Amo D, Wang W, Klivansky L, Liu Y, Marlow F, Wu P. Angew Chem Int Ed Engl. 2011 Jul
14. doi: 10.1002/anie.201101817. [Epub ahead of print]. PMID: 21761519.

Imaging glycans in zebrafish embryos by metabolic labeling and bioorthogonal click chemistry. Jiang H, Feng L, Soriano del Amo D, Marlow FL, and Wu P. J Vis Exp. 2011 Jun 6;(52). pii: 2686. doi: 10.3791/2686. PMID: 21673647.

Tracking of N-acetyllactosamine-bearing glycans on the cell surface in vivo. Zheng T, Jiang H, Gros M, Soriano del Amo D, Sundaram S, Lauvau G, Marlow FL, Stanley P, and Wu P. Angewandte Chemie. 2011; March. DOI: 10.1002/anie.201100265. PMID: 21472942.

Dynamic in vivo imaging using biocompatible copper (I) catalysts. Soriano del Amo D, Wang W, Jiang H, Besanceney C, Yan A, Levy M, Liu Y, Marlow FL and Wu P. JACs. 2010 Nov; 132: 16893. PMID: 21062072.

Microtubule Actin Crosslinking Factor 1 Regulates Balbiani Body Function and Animal-Vegetal Polarity of the Zebrafish Oocyte. Gupta T, Marlow FL, Ferriola D, Mackiewicz K, Dapprich J, Monos D, Mullins MC. PLoS Genet. 2010 Aug 19;
6(8):e1001073. PMID: 20808893.

Syntabulin, a linker of the motor protein, controls dorsal determination in zebrafish embryos. Nojima H, Röthhämel S, Shimizu T, Kim C, Yonemura S, Marlow FL & Hibi M. Development. 2010; Feb; 137: 923-933. PMID: 20150281.

hnRNP I/brom bones is required for Ca2+-mediated egg activation in the zebrafish. Mei W, Lee KW, Marlow FL, Miller AL, and Mullins MC. Development. 2009 Sept;136 (17):3007-17. PMID: 19666827.

Bucky ball organizes germ plasm assembly in the zebrafish oocyte. Bontems F*, Stein A*, Marlow F*, Lyautey J, Gupta T, Mullins MC and Dosch R. Current Biology. 2009. Feb 25; 19: 414-422 *Co-first authors. PMID: 19249209.

tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Alvarez-Delfin, K, Morris AC, Snelson C, Burgess H, Gupta T, Marlow F, Gamse JT, Mullins, MC, and Fadool JM. Proc Natl Acad Sci U S A.
2009 Feb 10; 106 (6): 2023-8. PMID: 19179291.

Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish. Marlow FL and Mullins MC. Dev. Bio. 2008 Sep 1; 321(1): 40-50. Published online June 9 2008. PMID: 18582455.

Migration of Zebrafish Primordial Germ Cells: a Role for Myosin Contraction and Cytoplasmic Flow. Blaser H, Reichman-Fried M, Castanon I, Dumstrei K, Marlow FL, Kawakami K, Solnica-Krezel L, Heisenberg C-P, and Raz E.
Developmental Cell 2006 Nov 11; (5): 613-27. PMID: 17084355.

No tail cooperates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Marlow F*, Gonzalez EM*, Yin C, Rojo C, and Solnica Krezel L. Development 2003 Dec 3; (131): 203-216. *equal authorship.

Zebrafish Rho Kinase 2 Acts Downstream of Wnt11 to Mediate Cell Polarity and Effective Convergence and Extension Movements. Marlow F, Topczewski J, Sepich D, Solnica-Krezel L. Current Biology 2002 Jun 4; 12(11): 876-84. PMID:12062050.4.

Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Jessen JR, Topczewski J, Bingham S, Sepich DS, Marlow F, Chandrasekhar A, Solnica-Krezel L. Nat Cell Biol. 2002 Aug 4; (8): 610-5. PMID: 12105418.

Role of the Zebrafish trilobite Locus in Gastrulation Movements of Convergence and Extension. Sepich DS, Myers DC, Short R, Topczewski J, Marlow F, Solnica-Krezel L. Genesis 2000 Aug 27; (4): 159-173.

Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Marlow F, Zwartkruis F, Malicki J, Neuhauss SC, Abbas L, Weaver M, Driever W, Solnica-Krezel L. Developmental Biology 1998 Nov 15; 203(2): 382-99. PMID: 9808788